FORMULASI GRANUL ANTIDIARE DARI EKSTRAK ETANOL DAUN KRATOM ( Mitragyna spesioca Korth)

FORMULATION GRANUL ANTIDIARE FROM KRATOM LEAF ETHANOL EXTRACT (Mitragyna spesioca Korth)

  • dian kartikasari Akademi Farmasi Yarsi Pontianak
  • suhaimi suhaimi
Keywords: Kratom extract, wet granulation and formula.

Abstract

Indonesian medicinal plants have been used both as traditional Indonesian medicine (herbal medicine), standardized herbal medicines or phytopharmaca. ethanol extract of kratom leaf (Mitragyna speciosa Korth) has been able to inhibit the growth of Escherichia coli bacteria and therefore researchers have developed a formula that is used as antidiarrheal, namely kratom leaf extract granule. The purpose of the concentration is avicel pH 101 that affects the physical properties of kratom leaf extract granules and on what formula meets the physical properties requirements of kratom leaf extract granules. The method used is the wet granulation method. With the ingredients used 5% kratom extract, evicel pH 101 and aerocil. By looking for the best aerosil pH 101 results and the best extract of kratom leaves, then the moisture content, flow time, angle of rest, and pH of the granule solution were evaluated. As for the results it can be concluded that the test carried out with 15% avicel concentration has a good effect on the physical granule Obtained the best formula is formula IV, it can be seen based on the test results fulfilling the granule requirements.

References

Kemenhut. (2013). For Pro,Majalah Ilmiah Populer Bidang Keteknikan Kehutanan dan Pengolahan Hasil Hutan, Vol.2, No.1, Edisi Juni 2013, ISSN:2301-8682, Pengembangan Produk HHBK Berbasis Tanaman Hutan,BPPK: Bogor, hal 24-25 (Diakses Pontianak tanggal 30 Oktober 2015 pukul 20:22)

Anna, H. (2013). Uji Efek Sedatif Ekstrak N-Heksan dari Daun Kratom (Mitragyna speciosa Korth.) pada Mencit Jantan Galur Balb/c . Program

Febriani Rizka L, 2018. Jurnal Insan Farmasi Indonesia Jilid 1 ISSN 2621 - 4032. Penetapan Parameter Standar Simplisia dan Ekstrak Etanol Daun Kratom (Mitragyna specioca Korth) yang Tumbuh Di Kabupaten Kapuas Hulu Dan Kabupaten Melawi. Pontianak : Akademi Farmasi Yarsi

Jawetz, Melnick., Adelberg. 2008. Mikrobologi Kedokteran Edisi 23.Jakarta. EGC.

Firlandi, 2017, Karya Tulis Ilmiah (KTI) Uji Daya Hambat Ekstrak Etanol Daun Kratom (Mitragyma specioca Korth) Terhadap Pertumbuhan Bakteri Escherichia Coli. Pontianak, Akademi Farmasi Yarsi. Kibbe, A,,H, 2004, Hanbook of Pharmaceutical Excipients, Third, Edition, 442, Pharmaceutical press, UK

Kibbe, A,,H, 2004, Hanbook of Pharmaceutical Excipients, Third, Edition, 442, Pharmaceutical press, UK

Supomo, Bella Dayang, 2015. Formulasi Granul Ekstrak Kulit Buah Manggis (Garcinia mangostana. L) menggunakan Aerosil dan Avicel pH 101, Samarinda: Akademi Farmasi Samarinda

Zeleny. 1982. Multiple Criteria Decision Making. Mc Graw Hill, New York.

Nugraha indri Widia,Robyanto, Luliana sri. 2018. Aktivitas AntinoSeptif Fraksi Daun Kratom (Mitragyna specioca Korth) pada Mencit Jantan Swiss. Fakultas Farmasi Universitas Tanjung Pura.

Novindriana dini. 2013 . Uji Efek Sedatif Ekstrak Etanolik Daun Kratom (Mitragyna specioca Korth ) Fakultas Kedokteran Universitas Tanjung Pura.

Lachman, Lieberman, kanig. Teori dan Praktek Farmasi 2, edisi III, Penerjemah Siti Suyatmi. Jakarta: Universitas Indonesia Press. 1994-10, 1531.

Published
2019-12-28
How to Cite
1.
kartikasari dian, suhaimi suhaimi. FORMULASI GRANUL ANTIDIARE DARI EKSTRAK ETANOL DAUN KRATOM ( Mitragyna spesioca Korth). JIFI [Internet]. 28Dec.2019 [cited 19Feb.2020];2(2):185-93. Available from: http://jiis.akfar-isfibjm.ac.id/index.php?journal=JIFI&page=article&op=view&path[]=378
Section
Articles