ANALISIS EFEKTIFITAS-BIAYA ANTARA KOMBINASI SALBUTAMOL-IPRATROPIUM DENGAN SALBUTAMOL PADA SERANGAN ASMA

  • Amelia Lorensia Uniersitas Surabaya
  • Ferdias Kurnia Bahari Fakultas Farmasi, Universitas Surabaya
Keywords: asthma exacerbation, cost-effectiveness analysis, ipratropium, salbutamol

Abstract

Treatment of asthma exacerbation is necessary to get attention to get effective and efficient treatment. The first line of treatment for asthma exacerbation is nebulation salbutamol, but some asthma treatments require additional combinations of ipratropium. know the cost-effectiveness with the use of a combination of salbutamol and ipratropium bromide with salbutamol alone to improve asthma symptoms and length of treatment in patients with asthma attacks. The study design was retrospective from medical record data of asthma patients in a hospital in Surabaya in the period from January-October 2017. Dependent variables were cost and clinical outcome (duration of treatment and loss of breathless symptoms). Data analysis used was ACER calculation and different test. The subjects were 64 people, consisting of 23 people in group A (salbutamol-ipratropium) and 41 people in group B (salbutamol). Group A was more cost-effective in length of treatment and trade-off in reducing asthma symptoms than in group B. There was no significant difference between costs (p(0.816)> 0.05), length of treatment (p=0.386)> 0.05)) and improvement of asthma symptoms (p (0.676)> 0.05). Therefore, further research was needed on the level o f other asthma attacks and other cost/outcome components.

References

Oemiati, R., Sihombing, M.Q. (2010). Faktor-Faktor yang Berhubungan dengan Penyakit Asma Di Indonesia, Media Litbang Kesehat., 20(1),pp.41-50.

Global Initiative for Asthma. (2019). Global Strategy for Asthma Management and Prevention (online), Available at: https://ginasthma.org/reports/2019-gina-report-global-strategy-for-asthma-management-and-prevention/ [diakses 1 Maret 2019].

Travers, A.H., Jones, A.P., Camargo, C.A., Milan, S.J., Rowe, B.H. (2012). Addition of Intravenous beta 2 -agonists to inhaled beta (2)-agonists for acute asthma, Cochrane Database Syst Rev., CD010256.

Lorensia, A., Ikawati, Z., Andayani, T.M., Maranatha, D., Wahjudi, M. (2016a). Comparison of electrolyte disturbance of using intravenous aminophylline versus nebulization salbutamol for exacerbation asthma in Surabaya, Indonesia, Int J Pharm Clin Res, 8(4),pp.221-228.

Lorensia, A., Wahjuningsih, E., Supriadi. (2012). Safety of Aminophylline for Asthma Therapy in Delta Surya Hospital at Sidoarjo, J Farm Klin Indones., 1(4),pp.154-161.

Lorensia, A., Ikawati, Z., Andayani, T.M., Maranatha, D. (2018). Perbandingan Perbaikan Nilai Peak Ekspiratory Flow Penggunaan Aminofilin dan Salbutamol pada Eksaserbasi Asma, Indones J Chest, 5(2),pp.34-43.

Das, S., Bandyopadhyay, A., Bhattacharya, S., Biswas, I., Bairagya, T. (2011). A comparative study of efficacy and safety of arformoterol and salbutamol nebulization as rescue therapy in acute non-severe asthma, Indian J Pharmacol., 43(4),pp.463.

Lorensia, A., Canggih, B., Wijaya, R.I. (2013a). Analisis Adverse Drug Reactions pada Pasien Asma di Suatu Rumah Sakit, Surabay,. J Farm Indones., 6(3),pp.142-150.

Lugogo, N.L., Maclntyre, N.R. (2008). Life-Threatening Asthma: Pathophysiology and Management, Respi Care, 53(6),pp.726-735.

Lorensia, A., Wijaya, R.I., Canggih, B. (2013b). Studi Efektifitas Biaya Terkait Pemilihan Obat Asma Bronkiale Rawat Inap di Suatu Rumah Sakit Swasta di Surabaya, J Ilm Sains Teknol., 7(1),pp.56-63.

Domínguez-Ortega, J., Phillips-Anglés, E., Barranco, P., Quirce, S. (2015). Cost-effectiveness of asthma therapy: a comprehensive review, J Asthma, 52(6),pp.529-537.

Lorensia, A., Wijaya, R.I. (2016b). Hubungan Jumlah Obat Yang Digunakan Terhadap Risiko Terjadinya Drug-Related Problems Pada Pasien Asma Di Suatu Rumah Sakit Di Surabaya, J Trop Pharm Chem., 3(4),pp.232-238.

Lorensia, A. (2018). Buku Ajar Farmakoekonomi: Menghadapi Tingginya Lonjakan Biaya Pengobatan Yang Mengancam Kestabilan Perekonomian. Surabaya: CV M-Brother.

Lorensia, A., Amalia, R.A. (2015) Studi Farmakovigilans pengobatan Asma pada Pasien Rawat Inap di Suatu Rumah Sakit Di Bojonegoro, J Ilm Manuntung, 1(1),pp.8-18.

Mafruhah, O.R., Syaputra, B., Sari CP. (2016). Evaluasi Efektivitas Terapi pada Pasien Asma di Rumah Sakit Khusus Paru Respira Yogyakarta Kalasan Periode November 2014-Januari 2015, Jurnal Ilmiah Farmasi, 12(2),pp.66-72.

Kirkland, S.W., Vandenberghe, C., Voaklander, B., Nikel, T., Campbell, S., Rowe, B.H. (2017). Combined inhaled beta-agonist and anticholinergic agents for emergency management in adults with asthma, Cochrane Database Syst Rev., 1, CD001284.

Cunnamaa, L., Sinanovic, E., Rammaa, L., Fostera, N., Berrie, L., Stevens, W., Molapo, S., Marokane, P., Mccarthy, K., Churchyard, G., Avassall, A. (2016). Using Top-Down and Bottom-Up Costing Approaches In LMICs: The Case for Using Both to Assess The Incremental Costs of New Technologies at Scale, Health Econ., 25(Suppl. 1),pp.53-66.

Olsson, T.M. (2011). Comparing top-down and bottom-up costing approaches for economic evaluation within social welfare, Eur J Heal Econ., 12(5),pp.445-453.

Meslin, E.M. (2010). The value of using top-down and bottom-up approaches for building trust and transparency in biobanking,. Public Health Genomics, 13(4),pp.207-214.

Indonesian Case Based Groups (INA-CBG’s) dan non Indonesian Case Based. (2016). Peraturan Menteri Kesehatan Republik Indonesia Nomor 52 Tahun 2016 Tentang Standar Tarif Pelayanan Kesehat Dalam Penyelenggaraan Progr Jaminan Kesehat.

Vézina, K., Chauhan, B.F., Ducharme, F.M. (2014). Inhaled anticholinergics and short-acting beta 2-gonists versus short-acting beta2-agonists alone for children with acute asthma in hospital, Cochrane Database Syst Rev., CD010283.

Published
2020-05-30
How to Cite
1.
Lorensia A, Bahari F. ANALISIS EFEKTIFITAS-BIAYA ANTARA KOMBINASI SALBUTAMOL-IPRATROPIUM DENGAN SALBUTAMOL PADA SERANGAN ASMA. JIFI [Internet]. 30May2020 [cited 16Jul.2020];3(1):38 -49. Available from: http://jiis.akfar-isfibjm.ac.id/index.php?journal=JIFI&page=article&op=view&path[]=470