FORMULASI ORALLY DISINTEGRATING TABLET (ODT) ASETOSAL DENGAN VARIASI KONSENTRASI KOMBINASI AVICE

  • Hayatus Sa'adah Akademi Farmasi Samarinda
  • Yulistia Budianti S. Akademi Farmasi Samarinda
  • Akhmad Andy Sandra Akademi Farmasi Samarinda
Keywords: orally disintegrating tablet, acetosal, Avicel PH 102, mannitol, direct compression method

Abstract

Acetylsalicylic acid or better known as acetosal or aspirin is a drug that has efficacy as an antiplatelet which is widely used as a drug to prevent and treat stroke. Currently acetosal is often found in many preparations, one of which is in conventional tablet preparations. Stroke sufferers really need a drug in tablet dosage form that is easy to consume, has a relatively fast duration of drug action, and with more practical drug administration. Therefore, an acetosal preparation is made in the form of Orally Disintegrating Tablet (ODT) which has several advantages, including being more practical to use because it can be consumed without using water and can be used by patients who are difficult to swallow conventional tablets. Research conducted on acetosal ODT formulation with variations in the combination concentration of Avicel PH 102 and mannitol as filler material. In this study, the physical properties of ODT acetosal were tested by varying the combination concentration of Avicel PH 102 and mannitol as a filler with a ratio of F1 = 0: 1, F2 = 0.25: 0.75, F3 = 0.5: 0.5 , F4 = 0.75: 0.25, and F5 = 1: 0. The ODT evaluation was carried out in the form of examining the weight uniformity test, hardness test, friability test, and tablet disintegrating time test. The results of the study obtained the best formula is F4 with a comparison of Avicel PH 102 and manitol 0.75: 0.25 that meets the requirements of physical properties of ODT with the average value of tablet weight uniformity test 382.5 mg ± 0.007, tablet 2 hardness test, 52 kg / cm2 ± 0.396, tablet friability test 0.53% ± 0.153, and tablet disintegrating time test 21 seconds ± 3.605.

References

Andersen, O., Zweidorff, O.K., Hjelde, T. dan E.A. Rodland. 1995. Problems When Swallowing Tablets: A Questionnaire Study from General Practice. Tidsskr. Nor. Laegeforen.

Bandari, S., Mittapalli, R.K., Gannu, R. dan Y.M. Rao. 2008. Orodispersible Tablets: An Overview. Asian J. Pharm.

Departemen Kesehatan Republik Indonesia. 1979. Farmakope Indonesia. Edisi Ketiga. Departemen Kesehatan Republik Indonesa. Jakarta.

Dhadve, Avinash. K dan Chander. P. Rathod. Formulation and Evaluation of Orodispersible Tablet (ODT) of Cinnarizine by Direct Compression Method: A Review. Indo American Journal of Pharmaceutical Research.

Hirani, J.J., Rathod, D.A., dan Vadalia, K.R. 2009. Orally Disintegrating Tablets: A Review. Topical Journal of Pharmaceutical Research.

Izza, Khawla A.A., Li, Vincent H., Look, Jee L., Parr, Graham D., dan Schineller, Matthew K. 2009. Fast Dissolving Tablet. Dalam : Bhupendra G Prajapati and Nayan Ratnakar. A Review on Recent Patents on Fast Dissolving Drug Delivery System. Int. J. Pharm. Tech. Research.

Koseki, T., Onishi, H., Takahashi, Y., Uchida, M. dan Y. Machida. 2008. Development of Novel Fast-Disintegrating Tablets by Direct Compression Using Sucrose Stearic Acid Esters as A Disintegration-Accelerating Agent. Chem. Pharm. Bull.

Kundu, S. dan P.K. Sahoo. 2008. Recent Trends in The Developments of Orally Disintegrating Tablet Technology. Pharma Times.

Lachman, L., Liebermann, H.A., dan J.I. Kanig. 1994. Teori dan Praktek Farmasi Industri. Edisi Ketiga. UI Press. Jakarta.

Siregar, C.J.P., dan Wikarsa, S. 2010. Teknologi Farmasi Sediaan Tablet. Penerbit Buku Kedokteran EGC. Jakarta.

Published
2019-03-31
How to Cite
Sa’adah, H., Budianti S., Y., & Sandra, A. (2019). FORMULASI ORALLY DISINTEGRATING TABLET (ODT) ASETOSAL DENGAN VARIASI KONSENTRASI KOMBINASI AVICE. Jurnal Ilmiah Ibnu Sina, 4(1), 31 - 39. https://doi.org/10.36387/jiis.v4i1.216
Section
Artikel