AKTIVITAS ANTIMALARIA PENGHAMBATAN POLIMERISASI HEME EKSTRAK ETANOL DAUN JAMBU BIJI (Psidium guajava) DAN DAUN PEPAYA (Carica papaya)

  • M. Arifuddin Fakultas Farmasi, Universitas Mulawarman, Samarinda
  • Mahfuzun Bone Fakultas Farmasi, Universitas Mulawarman, Samarinda
  • Rolan Rusli Fakultas Farmasi, Universitas Mulawarman, Samarinda
  • Hadi Kuncoro Fakultas Farmasi, Universitas Mulawarman, Samarinda
  • Islamuddin Ahmad Fakultas Farmasi, Universitas Mulawarman, Samarinda
  • Laode Rijai Fakultas Farmasi, Universitas Mulawarman, Samarinda
Keywords: Ethanol extract, Carica papaya, Psidium guajava, antimalarial, heme

Abstract

In an effort to find new sources of medicinal plants as antimalarials based on ethnobotany knowledge from generation to generation. Therefore, tested the inhibition of heme polymerization from 70% ethanol extract of papaya leaves (Carica papaya) and Guava (Psidium guajava) leaves. The data obtained were calculated by IC50 using SPSS 22 obtained that 70% ethanol extract of Pepaya leaves (Carica papaya) and Jambu Biji leaves (Psidium guajava) had antimalarial activities of 7,914 and 8,794 mg/ml respectively and their had the potential to be developed in more research further as antimalarial.

References

Abdillah, S., Tambunan, R., Sinaga, Y. and Farida, Y. (2014). Ethno-botanical survey of plants used in the traditional treatment of malaria in Sei Kepayang, Asahan of North Sumatera. Asian Pacific Journal of Tropical Medicine, 7, pp.S104-S107.

Abdillah, S., Tambunan, R., Farida, Y., Sandhiutami, N. and Dewi, R. (2015). Phytochemical screening and antimalarial activity of some plants traditionally used in Indonesia. Asian Pacific Journal of Tropical Disease, 5(6), pp.454-457.

Afshar, F.H., Delazar, A., Asnaashari, S., Vaez, H., Zolali, E., Asgharian, P. (2018). Screening of Anti-Malarial Activity of Different Extracts Obtained from Three Species of Scrophularia Growing in Iran. Iranian Journal of Pharmaceutical Research, 17(2): 668-676

Arifuddin, M., Bone., M. (2018). Skrining Fitokimia Dan Profil Kromatografi Lapis Tipis (KLT) Tumbuhan Antimalaria Asal Indonesia. Jurnal Sains dan Kesehatan

Basilico, N. (1998). A microtitre-based method for measuring the haem polymerization inhibitory activity (HPIA) of antimalarial drugs. Journal of Antimicrobial Chemotherapy, 42(1), pp.55-60.

Chong, C. R., Sullivan, D. J. (2003). Inhibition of heme crystal growth by antimalarials and other compounds: implications for drug discovery. Biochemical Pharmacology, 66(11), 2201-2212.doi:10.1016/j.bcp.2003.08.009

Due R., Symaswisna Dan Marlina, R. (2013). Etnobotani Tumbuhan Obat Suku Dayak Pesaguan Dan Implementasinya Dalam Pembuatan Flash Card Biodiversitas. Artikel Penelitian. Program Studi Pendidikan Biologi Fkip Untan Pontianak.

Egan, Timothy J., Kanyile K. Ncokazi. Quinoline Antimalarials Decrease the Rate of β-Hematin Formation. Journal of Inorganic Biochemistry, vol. 99, no. 7, 2005, pp. 1532–1539., doi:10.1016/j.jinorgbio.2005.04.013.

Francis S.E., Sullivan D.J., Goldberg D.E. (1997). Hemoglobin metabolism in the malaria parasite Plasmodium

falciparum. Annu Rev Microbiol 51: 97-123.

Joshi, S., Munshi, R., Talele, G., Shah, R. (2017). An experimental in vitro study to evaluate the antimalarial activity of select homeopathy preparations. International Journal of Medical and Health Research, Volume 3, Issue 7, Page No. 65-68.

Kumari, M., & Ghildiyal, R. (2014). Clinical Profile ofPlasmodium vivaxMalaria in Children and Study of Severity Parameters in relation to Mortality: A Tertiary Care Centre Perspective in Mumbai, India. Malaria Research and Treatment, 2014, 1-6. doi:10.1155/2014/765657

Kemenkes RI. (2016). Profil Kesehatan Indonesia 2015. Jakarta. http://www.depkes.go.id/resources/download/pusdatin/profil-kesehatan-indonesia/profil-kesehatan-Indonesia-2015.pdf

Leaman, D., Arnason, J., Yusuf, R., Sangat-Roemantyo, H., Soedjito, H., Angerhofer, C. and Pezzuto, J. (1995). Malaria remedies of the Kenyah of the Apo Kayan, East Kalimantan, Indonesian Borneo: A quantitative assessment of local consensus as an indicator of biological efficacy. Journal of Ethnopharmacology, 49(1), pp.1-16.

O’Neill, P. M., Barton, V. E., Ward, S. A. (2010). The Molecular Mechanism of Action of Artemisinin—The Debate Continues. Molecules, 15(3), 1705-1721. doi:10.3390/molecules15031705

Rathore D., Jani D., Nagrakatti R., Kumar S. (2006). Heme detoxification and anti-malarial drugs – known mechanisms and future prospects. Drug Discov Today Ther Strateg 3: 153-158.

Rosenthal, P. J. (2003). Antimalarial drug discovery: Old and new approaches. Journal of Experimental Biology, 206(21), 3735-3744. doi:10.1242/jeb.00589

Tripathi A.K., Gupta A., Garg S.K., Tekwani B.L. (2001). In vitro β-hematin formation assays with plasma of mice infected with Plasmodium yoelii and other parasite preparations comparative inhibition with quinoline and endoperoxide antimalarials. Life Sci 69: 2725-33.

Sari, R.Y., Wardenaar, E. dan Muflihati. 2014. Etnobotani Tumbuhan Obat Di Dusun Serambai Kecamatan Kembayan Kabupaten Sanggau Kalimantan Barat. Jurnal Hutan Lestari, Vol 2, No 3.

Sebisubi FM, Tan GT. 2011. Natural products with antimalarial activity, in Phytochemistry and Pharmacognosy section, Chemical Sciences, Engineering and Technology Resources. Encyclopedia of Life Support Systems (EOLSS), Developed under the Auspices of the UNESCO. EOLSS Publishers. Oxford, UK. (http://www.eolss.net).

Somsak, V., Polwiang, N., Chachiyo, S. 2016. In Vivo Antimalarial Activity of Annona muricata Leaf Extract in Mice Infected with Plasmodium berghei. Journal of Pathogens. Volume 2016, Article ID 3264070, 5 pages. doi.org/10.1155/2016/3264070

Surjadjaja, C., Surya, A., & Baird, J. K. (2016). Epidemiology of Plasmodium vivax in Indonesia. The American Journal of Tropical Medicine and Hygiene, 95(6 Suppl), 121-132. doi:10.4269/ajtmh.16-0093

WHO. (2017). World Malaria Report 2016. World Health Organization. Geneva. Available at: http://www.who.int/entity/malaria/publications/world-malaria-report-2016/WMR-2016-profiles.pdf [Accessed 1 Jul. 2017].

Published
2019-03-31
How to Cite
Arifuddin, M., Bone, M., Rusli, R., Kuncoro, H., Ahmad, I., & Rijai, L. (2019). AKTIVITAS ANTIMALARIA PENGHAMBATAN POLIMERISASI HEME EKSTRAK ETANOL DAUN JAMBU BIJI (Psidium guajava) DAN DAUN PEPAYA (Carica papaya). Jurnal Ilmiah Ibnu Sina, 4(1), 235 - 243. https://doi.org/10.36387/jiis.v4i1.246
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