PENGARUH PEMBERIAN SALEP EKSTRAK KUNYIT KUNING (Curcuma longa Linn) TERHADAP PENYEMBUHAN LUKA SAYAT PADA TIKUS PUTIH (Rattus norvegicus)

  • Muthia Milasari Program Studi Kedokteran Hewan, Fakultas Kedokteran, Universitas Hasanuddin
  • Abdul Wahid Jamaluddin Program Studi Kedokteran Hewan, Fakultas Kedokteran, Universitas Hasanuddin
  • Yuko Mulyono Adikurniawan Program Studi Kedokteran Hewan, Fakultas Kedokteran, Universitas Hasanuddin
Keywords: Curcumin, Yellow turmeric extract ointment, Rats, Wound healing

Abstract

Turmeric is one of the herbal contents substancials that believed help wound healing process. Scientifically, turmeric has been shown to have an anti-inflammatory and choleretic effect.  The curcumin compound has potential effects  as antimicrobial and antioxidant that can  accelerate the re-epithelialization and migration of cells such as myofibroblast, fibroblasts and macrophages. Those are compounds for wound healing.  The aims of this study is to know the effect of yellow tumeric extract oinment in wound healing based on the time of wound close and morphological changes are compared with the controls. This study was carried out by experimental test. The experimental animals were divided into 5 groups, each group consisted of 5 animals. Each group is treated, among others by giving 10%, 20%, and 30% yellow turmeric extract ointment (treatment groups), povidone iodine 10% ointment (positive control) and ointment base (negative control). The rats were given an incision in the back of the vertebrae with square pattern around ±2cm to fascia. Yellow turmeric extract ointment was applied to rat wounds 2 times a day and observed daily from day 1 to day 14. Data were analyzed using ANOVA (analysis of variance). The results showed a significant difference in 5 groups (P< 0.05). There were differences in the results of the study between the treatment group (10%, 20% and 30% yellow tumeric extract ointment), positive control (povidone iodine 10% ointment) and negative control group (ointment base) which showed a faster treatment group to heal wounds compared the control group. The study reveals that 10% yellow turmeric extract ointment is best in accelerating wound healing.

References

Ackerman, N dan Victoria, A., 2016, Aspinal’s Complete Textbook of Veterinary Nursing. Elsevier Health Sciences,UK.

Ahmad, A. dan Rauf P., 2018, Aktivitas Antikanker Senyawa Bahan Alam Kurkumin Dan Analognya Pada Tingkat Molekuler, Universitas Hasanuddin, Makassar.

Akram, M., 2010, Curcuma Longa and Curcumin, a review article, Rom.J.Biol.Plant

Albanese, F.,2017, Canine and Feline Skin Cytology, A Comprehensive and Illustrated Guide to the Interpretation of Skin Lesions via Cytological Examination, Springer International Publishing, Italy.

Andrie, M dan Dies S., 2017, Efektivitas Sediaan Salep yang Mengandung Ekstrak Ikan Gabus (Channa striata) pada Proses Penyembuhan Luka Akut Stadium II Terbuka pada Tikus Jantan Galur Wistar. Jurnal Kedokteran. 4 (2).

Angel DE, Morey P, Storer JG and Mwipatayi BP., 2008, The Great Debate Over Iodine in Wound Care Continues: A Review of The Literature. Wound Practice and Res. 16 (1): 6-21.

Arief M., 2005, Farmasetika, Gajah Mada University Press ,Yogyakarta.

Aspinal, V., 2014, Clinical Procedures In Veterinary Nursing Edition 3, Elsevier Health Sciences, UK.

Aspinall, V., Capello, M., 2015. Introduction to Veterinary Anatomy and Physiology Textbook, 3 Edition, Elsevier Ltd, London.

Aggarwal, B. B., A. Kumar ., M. S. Aggarwal dan S. Shishodia., 2010, Curcumin Derived from Turmeric (Curcuma longa): a Spice for All Seasons in Phytopharmaceuticals in Cancer Chemoprevention. N/A, N/A.

Balqis U, Frengky, Nur A, Hamdani, Dwinna A, dan T. Armansyah. 2016. Efikasi Mentimun (Cucumis Sativus L.) Terhadap Percepatan Penyembuhan Luka Bakar (Vulnus Combustion) De. Jurnal Medika Veterinaria Vol. 10 No. 2, Mei 2016.

Boyce, J. M. dan Pittet, D., 2002, Guideline for hand hygiene in health-care settings: Recommendations of the healthcare infection control practices advisory committee and the HICPAC/SHEA/APIC/IDSA. Hand hygiene task force. Infection Control and Hospital Epidemiology. 51 (RR-16) : 1-45.

Caldwell, F. 2014., How To Select An Appropriate Wound Dressing. Veterinary Hospital In Manchester. The Veterinary Nurse , Vol 5 No 2, UK.

CCAC., 1984, Laboratory Rats. Canadian Council on Animal Care: Guide to the care and use of experimental animals, volume 2.

Cochran, P.E., 2004, Laboratory Manual for Comparative Veterinary Anatomy and Physiology, Thomson Dermal Learning, Canada.

Cote, E., 2014, Clinical Vaterinary Advisor Dogs and Cats, Elsevier Health Sciences, Canada.

Dahlan, M., Sopiyudin., 2009, Statistik untuk Kedokteran dan Kesehatan, Salemba Medika, Jakarta.

Dejonckheere , V., 2016, Turmeric for Osteoarthritis in Veterinary Medicine, a Review. Veterinary Chiropractic Care, Acupuncture and Herbal Medicine.

Dharmojono, H., 2002. Kapita Selekta Kedokteran Veteriner, Edisi 2. PustakaPopuler Obor,Jakarta.

Doyle, R., 2012, Making Ends Meet: Wound Management and Closure in Dogs and Cats, VICAS, UK.

Elkhtam, A.O., Amera Abd El Latif.,M.H. El-Hewaity., 2014, Efficacy of turmeric (Curcuma longa) and garlic (Allium sativum) on Eimeria species in broilers. Department of Parasitology, Fac, Vet, Med, Sadat City University, Egypt, International Journal of Basic and Applied Sciences, 3 (3) (2014) 349-356.

Fairgrieve, M., 2012, The Natural Way For Dogs And Cats: Natural Treatments, Remedies And Diet For Your Pet, Random House, United Kingdom.

Fossum, T.W., 2013, Small Animal Surgery, Elsevier Inc, USA.

Fox, J.G., Anderson, L.C., Otto, G.M., Pritchett-Corning, K.R., Whary, M.T., 2015, American College Of Laboratory Animal Medicine Series 3 Edition, Elsevier Inc, USA.

Gladstar, R., 2012, Medicinal Herbs: A Beginner's Guide, Storey Publishing, USA.

Hamid, MA., 2011, Pengaruh Pemberian Rimpang Kunyit (Curcuma domestica vall.) Dalam Mempercepat Proses Penyembuhan Luka Bersih Pada Marmut (Cavia orcellus), The Indonesian Journal Of Health Science, Vol. 1, No. 2, Juni 2011

Harari, J., 2004, Small Animal Surgery Secrets, Hanley & Belfus, Inc, USA.

Harding, C.R. dan Anthony V.R., 2016, Dry Skin and Moisturizers: Chemistry and Function: Effects of Natural Moisturizing Factor and Lactic Acid Isomers on Skin Function, University of Cincinnati, Ohio UAS.

Hariana, A., 2009, Tumbuhan Obat Dan Khasiatnya Seri 2. Cet 7, Penebar Swadaya, Jakarta.

Hartati, S.Y dan Balittro., 2013, Khasiat Kunyit Sebagai Obat Tradisional Dan Manfaat Lainnya. Penelitian Dan Pengembangan Tanaman Industry Volume 19 No.2 Agustus 2013.

Holzman, G dan Teri R., 2015, Surgical Patient Care For Veterinary Technicians And Nurses, Wiley-Blackwell, USA.

Janvier Labs., 2013, Research Model: Sprague Dawley Rat. http://www.janvier-labs.com. [Diakses pada 9 Maret 2018].

Joenoes, N.Z., 2003, Resep yang Rasional, 137, Airlangga University Press, Surabaya.

Johnston, S.A dan Karen M.T., 2017, Veterinary Surgery : Small Animal Expert Consult, Elsevier, UK.

Kementerian Kesehatan Republik Indonesia., 2014, Farmakope Indonesia Edisi V, Jakarta, Direktorat Jenderal Bina Kefarmasian dan Alat Kesehatan.

Kielhorn, J., S. M. Kollmub, I. Mangelsdorf., 2006, Dermal Absorption, Environmental Health Criteria. 235.

Koolhaas, J.M.., 2010, The Laboratory Rat. In R. Hubrecht & J. Kirkwood, eds. The UFAW Handbook on The Care Management of Laboratory and Other Research Animal. UFAW, hal. 311–326.

Krinke G.J., 2000, The Handbook of Experimental Animals: The Laboratory Rat, Academic Press, London.

Lachman, L., A. H. Lieberman, dan J. L. Kanig.,1994, Teori dan Praktek Farmasi Industri, Terjemahan Siti Suyatmi, UI-Press, Jakarta.

Mayangsari, E., Bayu L., Setyawati S., Nurdiana., Nur P., Umi K., Husnul K., Dian N., 2017, Farmakologi Dasar, Universitas Brawijaya Press , Malang.

Merdekawati, D dan Rasyidah., 2017, Hubungan Prinsip Dan Jenis Balutan Dengan Penerapan Teknik Moist Wound Healing, Journal Endurance 2(1) :90-96.

Miah, M.A.H., Moinul H., Yousuf A.S., Md M. A., and Nasrin S.J. 2017, Clinical Evaluation Of Ethanolic Extract Of Curcumin (Curcuma Longa) On Wound Healing In Black Bengal Goats, Journal of Advanced Veterinary and Animal Research Vol 4 No 2, Pages 181-186.

Moriello, K.A., 2018, Structure of The skin In Dogs, MSD Veterinary Manual, USA.

Naibaho, O.H., Yamlean, P.V.Y., Wiyono, W., 2013. Pengaruh Basis Salep Terhadap Formulasi Sediaan Salep Ekstrak Daun Kemangi (Ocimum sanctum L.) Pada Kulit Punggung Kelinci yang Dibuat Infeksi Staphylococcus aureus. J. Ilm. Farm. 2, 27–34.

Novriansyah, R., 2008, Perbedaan Kepadatan Kolagen di Sekitar Luka Insisi Tikus Wistar Yang Dibalut Kasa Konvensional dan Penutup Oklusif Hidrokoloid Selama 2 dan 14 hari. Masters Thesis, Diponegoro University.

Orgil, D.P., 2009, Excision And Skin Grafting Of Thermal Burn. New England J. Med. 360:893-901.

Pavletic, M.M., 2010, Atlas of Small Animal Wound Management and Reconstructive Surgery, Third Edition, Blackwell Publishing, USA.

Purba, E.R. dan Martanto M.,2009, Kurkumin Sebagai Senyawa Antioksidan, Universitas Kristen Satya Wacana, Jawa Tengah.

Risselada, M., 2017, Wound Management, An Issue of Veterinary Clinics of North America: Small Animal Practice, Elsevier Health Science, North America.

Sari , A dan Amy M., 2016, Formulasi Sediaan Salep Ekstrak Etanol Rimpang Kunyit (Curcuma Longa Linn), Sel Vol. 3 No. 1 Juli 2016: 16-23

Sharp P.,Villano J., 2013, The Laboratory Rat, Second edition, CRC Press, Boca Raton.

Shelke U.Y dan Mahajan A.A., 2015, Review on: an Ointment, International Jurnal Of Pharmacy & Pharmaceutical Research Ijppr.Human, 2015; Vol. 4(2): 170-19.

Shrishail, D., Handral H.K., Handral R., G.Tulsianand dan S.D. Shruthi., 2013, Turmeric: Nature’s Precious Medicine, Asian J Pharm Clin Res, Vol 6, Issue 3, 2013, 10-16.

Sirois, M.., 2013, Elsevier’ s Veterinary Assisting Textbook, Elsevier Inc, Missouri.

Sirois, M., 2017, Elsevier’s Veterinary Assistant Textbook, Second Edition, Elsevier, China.

Sjahruddin , A.D., Anis Irawan A.,Farida T., Khairuddin D., Dasril D., Gemini A., 2015, The Effect of Curcumin on the Acute Wound Healing of Mice,American Journal of Clinical and Experimental Medicine 3(4): 189-193.

Sladky, K.K dan Christoph M., 2016, Soft Tissue Surgery, An issue of veterinary clinics of North Amerika, Exotic Animal Practice, Elsevier ,Philadelphia.

Slatter, D.H., 2003, Textbook of Small Animal Surgery, Volume 1, SAUNDERS, USA.

Sudidgo, S dan Ismael, S., 2002, Dasar-dasar Metodologi Penelitian Klinis Edisi Ke-2, Sagung Seto, Jakarta.

Swarjana, I.K., 2012, Metodologi Penelitian Kesehatan ed 1, ANDI,Yogyakarta.

Tangapazham RL, Sharma A, Maheshwari RK., 2007, Beneficial Role Of Curcumin In Skin Disease In The Molecular Targets And Therapeutic Uses Of Curcumin In Health And Disease, Springer, New York.

Tear, M., 2017, Small Animal Surgical Nursing, Third Edition,Elsevier Inc , Canada.

Tighe M.M dan Marg B.,2015, Mosby’s Comprehensive Review for Veterinary Technicians, Elsevier Inc,China.

Tobias, K.M. dan Johnston, S.A., 2012, Veterinary Surgery Small Animal, Elsevier Saunders, Missouri.

Wientarsih, I dan Febram B., 2006, Diktat Farmasi dan Ilmu Reseptir, Bagian Farmasi Pendidikan Profesi Dokter Hewan Institut Pertanian Bogor, Bogor.

Wientarsih, I., Wiwin W.L.,Noviyanti S., 2012, Aktivitas Penyembuhan Luka oleh Gel Fraksi Etil Asetat Rimpang Kunyit pada Mencit Hiperglikemik, Jurnal Veteriner Vol. 13 No. 3: 251-256.

Yanhendri, Yenny, S.Y., 2012, Berbagai Bentuk Sediaan Topikal dalam Dermatologi, Cdk-194 39, 423–430.

Yani, N.I.I., 2017, Uji Instrument Time Modifikasi Bates-Jensen Metode Checklist Di Rsud Prof. Dr. Margono Soekarjo Purwokerto, Fakultas Ilmu Kesehatan Universitas Muhammadiyah Purwokerto,Purwekerto. [Thesis]

Yunianto, B., Titik L., Agus W., 2017, Aktivitas Antibakteri Salep Dengan Bahan Aktif Ekstrak Kunyit, Kencur Dan Temugiring Terhadap Bakteri Staphylococcus Aureus, Jurnal Kebidanan Dan Kesehatan Tradisional, Volume 2, No 2, hlm 60-115.

Published
2019-03-31
How to Cite
Milasari, M., Jamaluddin, A., & Adikurniawan, Y. (2019). PENGARUH PEMBERIAN SALEP EKSTRAK KUNYIT KUNING (Curcuma longa Linn) TERHADAP PENYEMBUHAN LUKA SAYAT PADA TIKUS PUTIH (Rattus norvegicus). Jurnal Ilmiah Ibnu Sina, 4(1), 186 - 202. Retrieved from http://jiis.akfar-isfibjm.ac.id/index.php?journal=JIIS&page=article&op=view&path[]=268
Section
Artikel