TERATOGENIK EKSTRAK ETANOL UWI BANGGAI UNGU (Dioscorea alata L.) PADA MENCIT BETINA (Mus musculus)

  • Ihwan Ihwan Universitas Tadulako
  • Rahmatia Rahmatia Jurusan Farmasi,Fakultas MIPA, Universitas Tadulako
  • Khildah Khaerati Program Studi Farmasi FMIPA Universitas Tadulako
Keywords: Dioscorea alata L, Teratogenic, Mice

Abstract

Teratogenic is an abnormal development on embryo and is the cause of congenital defect or birth defect. This study aims to determine the effect of the addition of Dioscorea alata L.  ethanol extracts to the embryo development on pregnant mice whose given orally to 24 mice which divided to 4 treatment groups, they are the normal group (NG) with NaCMC 0.5%; 28 mg/KgBB treatment group; 35 mg/KgBB; 42 mg/Kg BB. The addition of Dioscorea alata L   ethanol extracts was done on the sixth day until the 15th day of pregnancy. On the 18th day of pregnancy, Laparaktomi was done to the pregnant mice and the embryo was taken out of the uterus. The observation was done to the fetus numbers, weight weighing of the fetus's body, dan length measurement of the fetus's body. Another observation is the observation of the external organ defect of the embryo. The study results that the addition of Dioscorea alata L ethanol extracts with various doses have no significant effect (P>0.5) to the mice external fetus development. On the examination of the fetus, we can conclude that Dioscorea alata L  ethanol extracts don’t give any effect that may cause the defect of the fetus’ external organ.

References

Anfiandi, V. (2013). Uji Teratogenik Infusa Daun Pegagan (Centella asiatica L. Urban) Pada Mencit Betina. Jurnal Ilmiah Mahasiswa Universitas Surabaya, 2(1), 3.

Anisa, I. N., Muslimah, I., Sutjiatmo, A. B., & Soemardji, A. A. (2014). Uji Teratogenik Ekstrak Air Daun Kecubung Gunung (Brugmansia suaveolens Bercht & Presl.) Pada Tikus Wistar. Jurnal Ilmiah Farmasi, 2(1), 22.

Christianty, F. M., & Winarti, L. (2012). Uji Teratogenik Campuran Serbuk Biji Jinten Hitam (Nigella sativa L.), Biji Klabet (Trigonella foenum-graecum L.), dan Ginseng (Panax ginseng C. A. Mey.) Pada Tikus Putih Galur Wistar, 9(3), 155.

Hapsari, R. T. (2014). Prospek Uwi Sebagai Pangan Fungsional dan Bahan Diversifikasi Pangan, (27), 26–38.

Hilmarni, Rahmawati, U., & Ranova, R. (2017). Uji Efek Teratogenik Ekstrak Etanol Daun Wungu (Graptophyllum pictum (L.) Griff) Pada Mencit Putih. Jurnal Farmasi Dan Kesehatan, 7(2), 151–152.

Muna, L. (2010). Uji Teratogenik Ekstrak Pandanus conoideus Lam. Varietas Buah Kuning Terhadap Perkembangan Embrio Tikus Putih (Rattus norvegicus).

Ong, A. K. (2013). Uji Teratogenik Ekstrak Etanol Daun Alpukat (Persea americana Mill) Pada Mencit Betina (Mus Musculus). Jurnal Ilmiah Mahasiswa Universitas Surabaya, 2(1), 9.

Riset Kesehatan Dasar. (2007). Riset Kesehatan Dasar, 279.

Setiawan, C. (2009). Efek Teratogenik Kombucha Pada Tikus Putih (Rattus norvegicus L.) Galur Wistar, 12–13.

Silvia, G. A. N. (2011). Pengaruh Pemberian Suspensi Sari Akar Manis Terhadap Perkembangan Janin Pada Mencit Bunting, 17–18.

Sulastra, C. S., & Khaerati, K. K. K. (2020). Toksisitas Akut Dan Lethal Dosis (Ld50) Ekstrak Etanol Uwi Banggai Ungu (Dioscorea Alata L.) Pada Tikus Putih (Rattus norvegicus). Jurnal Ilmiah Medicamento, 6(1), 10-14.

Yalindua, A. (2014a). Potensi Genetik Klon Tanaman Uwi ( Dioscorea alata L.) Asal Banggai Kepulauan Sebagai Sumber Pangan Dalam Menunjang Ketahanan Pangan Nasional.

Published
2020-10-27
How to Cite
Ihwan, I., Rahmatia, R., & Khaerati, K. (2020). TERATOGENIK EKSTRAK ETANOL UWI BANGGAI UNGU (Dioscorea alata L.) PADA MENCIT BETINA (Mus musculus). Jurnal Ilmiah Ibnu Sina, 5(2), 309-318. https://doi.org/10.36387/jiis.v5i2.511
Section
Artikel